Comprehensive identification and characterization of the binding sites of polymerase II

Comprehensive identification and characterization of the binding sites of polymerase II in mammalian genes were attempted. We used ChIP-Seq method, in which next gene sequencing technology and chromatin-immunoprecipitation assay were combined.

本研究尝试对哺乳动物基因中聚合酶II（polymerase II）的结合位点开展全面鉴定与特征解析工作。我们采用染色质免疫共沉淀测序（ChIP-Seq）技术，该技术将下一代基因测序技术与染色质免疫沉淀实验相结合。