Mycosis fungoides whole exome sequencing samples

The cohort corresponds to 67 mycosis fungoides (MF) skin tumor samples and 3 normal skin samples by whole exome sequencing (WES) from 48 patients from the hospital in Lille, France. The samples were collected between 2003 and 2017. There are 10 additional normal blood samples that were used to bioinformatically remove sequencing artifacts and for the building of the Panel of Normal. The objective of the analysis was to characterize the genetic profile of MF by identifying recurrent somatic mutations/copy numbers, mutational signatures, and clonal evolution in patients (some of whom had sequential samples).

本队列包含来自法国里尔某医院48名患者的67份蕈样肉芽肿（mycosis fungoides, MF）皮肤肿瘤样本与3份正常皮肤样本，所有样本均通过全外显子组测序（whole exome sequencing, WES）完成检测。样本采集于2003年至2017年间。另纳入10份正常血液样本，用于通过生物信息学手段去除测序伪影，并构建正常对照面板（Panel of Normal）。本分析旨在通过鉴定患者（部分患者拥有连续采样样本）中的复发性体细胞突变/拷贝数变异、突变特征与克隆演化情况，解析蕈样肉芽肿的遗传特征谱。