Characteristics of patients at randomization.^*

*From New England Journal of Medicine, Ovarian toxicity from sirolimus, Braun M, Young J, Reiner CS, Poster D, Wüthrich RP, Serra AL. 366(11):1062-4. Copyright © (2012) Massachusetts Medical Society. Reprinted with permission. †The body-mass index (BMI) is the weight in kilograms divided by the square of the height in meters. §The glomerular filtration rate (GFR) was estimated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation [48]. ¶Chronic kidney disease was classified according to the Kidney Disease Outcomes Quality Initiative of the National Kidney Foundation. Stage 1 denotes a glomerular filtration rate (GFR) of 90 ml or more per minute per 1.73 m2 of body-surface area; stage 2, a GFR of 60 to 89 ml per minute; and stage 3, a GFR of 30 to 59 ml per minute. ‡Patients' self-reported medical histories at randomization.* 源自《新英格兰医学杂志》，《西罗莫司的卵巢毒性》，作者为Braun M、Young J、Reiner CS、Poster D、Wüthrich RP、Serra AL。刊载于366(11):1062-4。版权归2012年马萨诸塞州医学协会所有。经许可转载。 † 体质量指数（body-mass index, BMI）为体重（千克）除以身高（米）的平方。 § 肾小球滤过率（glomerular filtration rate, GFR）采用慢性肾脏病流行病学合作研究（Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI）公式估算[48]。 ¶ 慢性肾脏病的分期依据美国国家肾脏基金会的肾脏病预后质量倡议（Kidney Disease Outcomes Quality Initiative）标准：1期指肾小球滤过率（GFR）≥90 ml·min⁻¹·(1.73 m²)⁻¹；2期为GFR 60~89 ml·min⁻¹；3期为GFR 30~59 ml·min⁻¹。 ‡ 患者随机分组时自述的病史。