Gut microbiota profile and plasma metabolome and lipidome in type 1 diabetes without and with stratification by albuminuria. PROTON

In a cross-sectional study we included 161 individuals with type 1 diabetes and 50 healthy control individuals. Individuals with type 1 diabetes were categorised into three groups according to historically measured albuminuria: (1) normoalbuminuria (<3.39 mg/mmol); (2) microalbuminuria (3.39–33.79 mg/mmol); and (3) macroalbuminuria (≥33.90 mg/ mmol). From faecal samples, the gut metagenome was analyzed by whole genome sequencing, comparing both taxonomical and functional profiles

本横断面研究共纳入161名1型糖尿病患者与50名健康对照个体。研究人员根据既往检测的白蛋白尿水平，将1型糖尿病患者划分为三组：(1) 正常白蛋白尿（normoalbuminuria，<3.39 mg/mmol）；(2) 微量白蛋白尿（microalbuminuria，3.39–33.79 mg/mmol）；(3) 大量白蛋白尿（macroalbuminuria，≥33.90 mg/mmol）。研究人员对粪便样本开展全基因组测序，分析肠道宏基因组（gut metagenome），并对其分类学特征与功能特征进行对比分析。