Additional file 2 of Gut microbiome for predicting immune checkpoint blockade-associated adverse events

Additional file 2: Fig S1. Alpha and beta diversity analysis in each cohort. Fig S2. Confounder analysis for model construction. Fig S3. Wilcoxon rank-sum test for the relative abundance comparison within 14 model species. Fig S4. Model evaluation in machine learning. Fig S5. Integrated analysis with colon tissue RNA sequencing and 16S rRNA amplicon sequencing. Fig S6. Qualitative analysis on menaquinone in key microbes.

补充文件2：图S1 各队列的α多样性与β多样性分析。图S2 模型构建的混杂因素分析。图S3 14个模式物种相对丰度比较的威尔科克森秩和检验（Wilcoxon rank-sum test）。图S4 机器学习模型评估。图S5 结肠组织RNA测序（RNA sequencing）与16S rRNA扩增子测序（16S rRNA amplicon sequencing）的整合分析。图S6 关键微生物中甲基萘醌（menaquinone）的定性分析。