Synthetic Applications of Cyanoacetylated Bisindoles: Synthesis of Novel Cycloheptadiindoles, Indolocarbazoles, and Related Aza Analogues

Cyclization reactions involving cyanoacetylated bisindoles
have been studied, providing access to various novel cyclohepta[2,1-b:3,4-b‘]diindole derivatives as well as some related
fused pentacyclic systems. Treatment of 3-cyanoacetyl-2,3‘-diindolylmethane with methanesulfonic acid gave 6-(cyanomethyl)indolo[3,2-b]carbazole in a good yield.

本研究针对氰乙酰化双吲哚（cyanoacetylated bisindoles）参与的环化反应开展了系统探究，成功获得多种新型环庚并[2,1-b:3,4-b']二吲哚衍生物（cyclohepta[2,1-b:3,4-b‘]diindole derivatives）以及若干相关稠合五环体系。以3-氰乙酰基-2,3'-二吲哚甲烷（3-cyanoacetyl-2,3‘-diindolylmethane）为底物，经甲磺酸（methanesulfonic acid）处理后，以良好收率得到6-(氰甲基)吲哚并[3,2-b]咔唑（6-(cyanomethyl)indolo[3,2-b]carbazole）。