MicroRNA Profiling of Surgical Myectomy Tissue from Patients with Hypertrophic Cardiomyopathy

Using a high-throughput gene expression profiling technology, we have illuminated novel potential microRNA (miRNA) components of the molecular disease process underlying human hypertrophic cardiomyopathy (HCM). It is hoped that this will fuel future research endeavors that will eventually uncover the role miRNAs may play in the phenotypic heterogeneity of the disease, and thus, provide potential tools for identifying patients with benign versus malignant forms of the disease. Case (n = 107)-Control (n=20) study comparing the microRNA transcriptome of cardiac tissues from patients with hypertrophic cardiomyopathy to the microRNA transcriptome of control donor cardiac tissues.

本研究采用高通量基因表达谱分析技术，揭示了人类肥厚型心肌病 (hypertrophic cardiomyopathy, HCM) 分子发病进程中潜在的新型微小RNA (microRNA, miRNA) 相关组分。本研究期望能够推动后续相关研究工作，最终明确miRNA在该疾病表型异质性中所发挥的作用，进而为区分良性与恶性表型的肥厚型心肌病患者提供潜在的辅助诊断工具。本研究为病例（n=107）-对照（n=20）研究，对比了肥厚型心肌病患者心脏组织与健康供体心脏组织的miRNA转录组。