STUDY ON EFFECTS OF PROBIOTICS ON WHOLE GUT MICROBIOME AND CLINICAL COURSE IN PATIENTS WITH CRITICAL CARE ILLNESSES

Ventilator Associated Pneumonia (VAP) is thought to be secondary to bacterial colonization of the upper digestive tract and aspiration of contaminated secretions into lower airway. Probiotics are postulated to prevent colonization of these pathogenic bacteria. In this prospective observational study, we aimed to investigate the effects of probiotics on gut microbiota and its relation with clinical outcomes in mechanically ventilated patients.

呼吸机相关性肺炎（Ventilator Associated Pneumonia, VAP）被认为继发于上消化道的细菌定植，以及受污染分泌物误吸进入下呼吸道。益生菌被假定可预防此类病原菌的定植。本项前瞻性观察性研究旨在探讨益生菌对机械通气患者肠道菌群的影响，及其与临床结局之间的关联。