Impact of fructooligosaccharides supplementation on microbiota composition in high-fat diet fed animals

Wild-type mice were fed for 4 weeks with a chow diet (CD), a high-fat diet (HFD) or a HFD supplemented with fructooligosaccharides (FOS) (HFD+FOS) administered in the drinking water. We evaluated the impact of HFD on microbiota composition and whether HFD-induced dysbiosis is reverted upon fructooligosaccharides supplementation.

将野生型小鼠（wild-type mice）分为三组，分别以普通饲料饮食（chow diet, CD）、高脂饮食（high-fat diet, HFD），或饮水添加低聚果糖（fructooligosaccharides, FOS）的高脂饮食（HFD+FOS）喂养，持续4周。本研究评估了高脂饮食对菌群组成（microbiota composition）的影响，以及高脂饮食诱导的菌群失调（dysbiosis）是否可通过补充低聚果糖得到逆转。