deBack2013 - Pancreas differentiation patterning in spatio-temporal multicellular model

This model reproduces a solution (at a=1, b=20.8, eta=1e-4) of the parameter scan in Fig. 4b of the referenced paper. Equations and other parameter values are as published. Notch signaling in competition with lateral stabilization, both mediated by cell–cell interactions, can control the cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages and yield a scattered spatial distribution of endocrine cells, major constituents of the later islets of Langerhans. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus (download from https://morpheus.gitlab.io) to simulate the time course (movie) of lineage specification in 10.000 coupled cells in the early pancreatic tissue.

本模型复现了参考文献论文中图4b的参数扫描结果中的一组解（参数取值为a=1、b=20.8、eta=1e-4）。其余方程与参数取值均与已发表文献中的内容一致。Notch信号通路（Notch signaling）与侧向稳定作用相互竞争，二者均由细胞间相互作用介导，可调控多能胰腺祖细胞在外分泌谱系与内分泌谱系之间的细胞命运抉择，并促使内分泌细胞呈现散在的空间分布；内分泌细胞是日后形成朗格汉斯岛（Islets of Langerhans）的主要组成成分。本模型文件采用MorpheusML格式，可在免费开源的多细胞建模软件Morpheus（可从https://morpheus.gitlab.io下载）中打开，以模拟早期胰腺组织中10000个耦合细胞的谱系特化时间进程（附带动态模拟影片）。