Effect of Early Growth Hormone Treatment on Long-term Growth and Skeletal Maturation in Girls With Turner Syndrome

This is an extension study that will gather long-term data on the effect of early growth hormone (GH) treatment on adult height and other aspects of health and development in girls with Turner syndrome. The main purpose is to determine whether girls who received 2 years of GH treatment before 6 years of age achieve taller adult height than girls who were untreated during this time. The study will also look at middle ear and hearing function, and cognitive and behavioral development. Protocol completion is defined as attainment of height velocity less than or equal to 1.0 cm/year, or bone age greater than or equal to 15 years.

本研究为一项延伸性研究，将收集长期数据以探究早期生长激素（growth hormone, GH）治疗对特纳综合征（Turner syndrome）女童的成年终身高及其他健康与发育维度的影响。本研究的核心目标为明确：6岁前接受2年生长激素治疗的特纳综合征女童，其成年终身高是否高于同期未接受该治疗的女童。本研究同时将评估受试女童的中耳与听力功能、认知及行为发育状况。本研究的方案完成标准定义为：身高生长速率≤1.0 cm/年，或骨龄≥15岁。