NHLBI TOPMed: Determining the Association of Chromosomal Variants with Non-PV Triggers and Ablation-Outcome in AF (DECAF)

The DECAF trial was conducted at the Texas Cardiac Arrhythmia Institute (TCAI) in 2013 in collaboration with the University of Texas at Austin. Four hundred consecutive AF patients undergoing catheter ablation were enrolled. All participants provided voluntary informed consents. Blood samples were collected before the ablation procedure and labeled with anonymous patient identifier. The researchers at UT Austin responsible for DNA extraction and genetic analysis were blinded about the clinical characteristics and identification of the study participants. AF cases included adults >18 years of age from both sex and all AF types.

DECAF试验于2013年由德克萨斯心脏心律失常研究所（Texas Cardiac Arrhythmia Institute, TCAI）与德克萨斯大学奥斯汀分校（University of Texas at Austin, UT Austin）合作开展。研究连续纳入400例行导管消融术的心房颤动（Atrial Fibrillation, AF）患者，所有受试者均签署自愿知情同意书。在导管消融术前采集血液样本，并以匿名患者标识符进行标记。负责DNA提取与基因分析的UT Austin研究人员，对研究受试者的临床特征与身份信息采取盲法处理。本研究纳入的心房颤动病例均为18周岁以上的两性受试者，涵盖所有类型的心房颤动。