Protein-protein interactions of HCMV virion proteins that have either been previously reported or suggested, and were positive in our YTH and co-IP analysis.

Interactions marked by an asterisk represent reciprocal interactions. “+” represents positive interactions identified by co-IP experiments in human cells (co-IP). The ORFs in which deletion results in no viral growth, wildtype-like growth, and significant growth defect in foreskin fibroblasts are marked as “E” (essential), “NE” (non-essential), and “D” (defect) [7].

带星号标注的相互作用为双向相互作用。符号"+"代表经人类细胞免疫共沉淀（co-IP）实验验证的阳性相互作用。若开放阅读框（Open Reading Frame, ORF）的缺失会导致病毒无法增殖、呈现野生型样增殖，或在包皮成纤维细胞中出现显著增殖缺陷，则分别将其标记为"E"（必需，essential）、"NE"（非必需，non-essential）与"D"（缺陷型，defect）[7]。