Parameters characterizing mitral spike responses to CCK receptor agonists.

First three rows list descriptive parameters under control conditions for three classes of CCK-8S spike response: excitatory, mixed excitatory-suppressive, and suppressive (data pooled for 300 nM and 1 µM CCK-8S; there was no significant difference between the two concentrations). For multiphasic responses caused by spike inactivation (e.g. Fig. 3C), duration of excitation was calculated using the end of the second excitatory peak. Next two rows list parameters of spike responses to 1 µM CCK-8S recorded in the presence of blockers of fast synaptic transmission. Last three rows list parameters of responses to 1 µM CCK-4, for 3 spike response classes: excitatory, mixed excitatory-suppressive, and suppressive. Values are expressed as mean ± SEM. Latencies were measured from time of CCK perfusion switch (including ∼50–80 s perfusion lag) to time of deviation from mean basal spike rate (p<0.01), and durations were computed from time points when responses deviated above or below (p<0.01) mean basal spike rate. Rate delta values for CCK responses are peak increments in spike rate relative to basal spike rate (positive for excitatory, negative for suppressive responses).

前3行列出了三类胆囊收缩素8S（CCK-8S）锋电位响应在对照条件下的描述性参数：兴奋性、兴奋性-抑制性混合型以及抑制性（本研究合并了300 nM与1 µM浓度的CCK-8S实验数据，两种浓度间无显著统计学差异）。对于由锋电位失活引发的多相响应（例如图3C），兴奋时段的时长以第二个兴奋性峰的结束时刻作为计算终点。后续2行列出了在快速突触传递阻断剂存在环境下，记录得到的1 µM CCK-8S刺激所诱发的锋电位响应参数。最后3行列出了三类锋电位响应（兴奋性、兴奋性-抑制性混合型、抑制性）在1 µM胆囊收缩素4（CCK-4）刺激下的响应参数。所有数值均以平均值±标准误（mean ± SEM）的形式呈现。潜伏时长的测量起点为CCK灌流切换时刻（包含约50–80 s的灌流延迟），终点为锋电位发放速率偏离基础平均发放速率的时刻（p<0.01）；响应时长则从锋电位发放速率偏离基础平均发放速率（上偏或下偏，p<0.01）的时间点开始计算。CCK响应的速率变化值（rate delta）指锋电位发放速率相对于基础发放速率的峰值变化量：兴奋性响应为正值，抑制性响应为负值。