Gold-Catalyzed Intramolecular Indole/Alkyne Cyclization Cascades through a Heterolytic Fragmentation: 1,5-Indole Migration and Allenylation

Gold-catalyzed intramolecular reactions of 3-alkynyl-bearing indoles with diol groups lead to the formation of highly functionalized 3-allenylindoles with high efficiency. The reaction likely proceeds by a new gold-catalyzed cascade cyclization/heterolytic fragmentation/elimination reactions, which results in 1,5-indole migration and C-3 allenylation of indole moiety.

含二醇基团的3-炔基吲哚（indole）的金催化分子内反应，可高效生成高官能团化的3-联烯基吲哚。该反应可能经由一条新型金催化的级联环化/异裂碎裂/消除反应路径进行，最终实现1,5-吲哚迁移与吲哚结构单元的C-3位联烯基化。