The Impact of high membrane permeability of ciprofloxacin loaded liposomes and its downregulation effect on MepA and NorB efflux pump of Methicillin-Resistant Staphylococcus aureus

The improved effectuality of ciprofloxacin liposome encapsulated (CFL) compared to ciprofloxacin is probably due to bypassing efflux pumps and therefore the high sustained bactericidal concentrations of ciprofloxacin within the bacterial cell.

与环丙沙星相比，脂质体包封环丙沙星（ciprofloxacin liposome encapsulated，CFL）的药效提升可能源于其可绕过细菌外排泵，进而在细菌细胞内维持高浓度且持续的环丙沙星杀菌浓度。