Genomewide temporal landscape of DNA methylation in pregnant women delivering at term in GARBH-InI cohort

Genome wide DNA methylation profiling of peripheral blood DNA collected from pregnant individuals throughout three time points (11-14 weeks, 18-20 weeks, 26-28 weeks) across the period of gestation and at term delivery (>37 weeks of gestation). Illumina Infinium EPIC Human DNA methylation Beadchip v1.2.8 was used to obtain DNA methylation profiles across approximately 850k CpGs. Maternal peripheral blood samples were collected in EDTA vacutainers. The goal was to identify temporal DNA methylation changes in maternal peripheral blood during the period of gestation and associate their impact on biological pathways critical for term delivery. Genome wide DNA methylation profiling of peripheral blood DNA collected from pregnant individuals throughout the period of gestation and at delivery. The Illumina Infinium EPIC Human DNA methylation Beadchip v1.2.8 was used to obtain DNA methylation profiles across approximately 850k CpGs. Maternal peripheral blood samples were collected in EDTA vacutainers. (contributor) GARBH-Ini Team

本数据集针对妊娠个体的外周血DNA开展全基因组DNA甲基化谱分析（Genome wide DNA methylation profiling），样本采集于妊娠期内三个时间节点（孕11-14周、18-20周、26-28周）以及足月分娩时（妊娠>37周）。研究采用Illumina Infinium EPIC人类DNA甲基化芯片v1.2.8（Illumina Infinium EPIC Human DNA methylation Beadchip v1.2.8），获取约85万个CpG位点（CpGs）的DNA甲基化谱数据。孕产妇外周血样本采用EDTA真空采血管（EDTA vacutainers）采集。本研究旨在解析妊娠期孕产妇外周血中DNA甲基化的动态变化，并明确其对足月分娩关键生物学通路的影响。针对妊娠期及分娩期采集的妊娠个体外周血DNA开展全基因组DNA甲基化谱分析。采用Illumina Infinium EPIC人类DNA甲基化芯片v1.2.8，获取约85万个CpG位点的DNA甲基化谱数据。孕产妇外周血样本采用EDTA真空采血管采集。（贡献团队）GARBH-Ini团队