Glucagon-like peptide alters hepatic ketone metabolism in the Pacific spiny dogfish

No effects of chondrichthyan glucagon-like peptide were found on spiral valve. GLP-3 exerts metabolic effects on ketone, but not glucose liver metabolism, as shown by a switch from endogenous consumption to production of ketones, paired with increases in transcript abundance of putative ketone transporters and the activity of B-hydroxybutyrate dehydrogenase in the liver. Unique actions indicate early putative actions of GLP in vertebrate evolution.

 软骨鱼（chondrichthyan）来源的胰高血糖素样肽（glucagon-like peptide）对螺旋瓣（spiral valve）无显著作用。胰高血糖素样肽3（GLP-3）可对酮体产生代谢调控效应，但不影响肝脏葡萄糖代谢：具体表现为酮体代谢从内源消耗转向酮体生成，同时肝脏内推定酮体转运蛋白的转录本丰度显著升高，且β-羟丁酸脱氢酶（B-hydroxybutyrate dehydrogenase）活性增强。上述独特的作用模式提示，胰高血糖素样肽在脊椎动物演化早期即已具备推定的生理功能。