Epigenetic misactivation of a distal developmental enhancer drives SOX2 overexpression in multiple cancer subtypes. Epigenetic misactivation of a distal developmental enhancer drives SOX2 overexpression in multiple cancer subtypes

We have investigated a distal regulatory region that drives SOX2 overexpression in multiple cancer subtypes Overall design: WT and homozygous enhancer-deleted (dEnh) cells were submitted for ribo-depelted total RNA-seq and ATAC-seq in three replicates each.

本研究针对驱动多种癌症亚型中SOX2过表达的远端调控区域展开了探究。实验设计概述：野生型（WT）与纯合增强子敲除（dEnh）细胞各设置三次生物学重复，分别进行去核糖体总RNA测序（ribo-depleted total RNA-seq）与转座酶可及性染色质测序（ATAC-seq）。