miRNA in BEAS-2B lung epithelial cells response to PRMT1 in vitro

Our previous studies proved that both epithelial inflammation and sub-epithelial remodeling were linked to deregulated PRMT1 expression in asthma patients. This sncRNA-seq data from the BEAS-2B cell line after over-expressed PRMT1 for 24h. Overall design: miRNA profiles of BEAS-2B cell lines were generated by deep sequencing using BGI-500. Sequencing reads filtering and bioinformatic analysis was also performed by BGI

我们既往的研究已证实，哮喘患者体内的上皮炎症与上皮下重塑均与蛋白精氨酸甲基转移酶1（PRMT1）的表达失调存在关联。本数据集为过表达蛋白精氨酸甲基转移酶1（PRMT1）24小时后，来自BEAS-2B细胞系的小非编码RNA测序（sncRNA-seq）数据。实验整体设计：采用BGI-500平台通过深度测序获取BEAS-2B细胞系的微小RNA（miRNA）表达谱。测序读段过滤与生物信息学分析亦由BGI完成。