User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with a staked 8 mm ultra-thin wall needle

User experience was compared between a new pre-fillable 2.25 mL glass syringe equipped with an ultra-thin-wall (UTW) 8 mm staked needle and a marketed BD Neopak™ syringe equipped with a special-thin-wall (STW) 12.7 mm staked needle. Participants simulated subcutaneous injections with both syringes alone (formative Human Factors study) and in combination with a needlestick-prevention device (validation Human Factors study). Usability results of both studies showed higher success rates for delivering the full dose of 2 mL viscous solution (30 cP) with the 8mmUTW syringe than with the 12.7mmSTW one (63% vs. 42% in the formative study). The use of the 8mmUTW syringe demonstrated also better ease of use and acceptance results and 72% of formative study participants preferred this new syringe over the current one when delivering the viscous solution. Using a shorter needle also showed a benefit in decreasing the injection-related anxiety. Besides, in the case of a non-recommended injection technique, the calculated risk of accidental intramuscular injection is reduced by 2 to 13 times with the 8mmUTW syringe. Altogether, the results obtained demonstrated an improvement of the user experience with this new syringe compared to the current one in the manual delivery of 2 mL viscous solutions.

本研究对比了两款注射器的用户体验：一款为新型预充式2.25 mL超薄壁（ultra-thin-wall, UTW）8mm固定针（staked needle）玻璃注射器，另一款为市售BD Neopak™特薄壁（special-thin-wall, STW）12.7mm固定针注射器。受试者分别单独使用两款注射器进行模拟皮下注射操作（形成性人机工效学研究），并搭配防针刺伤装置（needlestick-prevention device）开展模拟注射操作（验证性人机工效学研究）。两项研究的可用性评价结果均显示，使用8mm UTW注射器完成2 mL 30厘泊（centipoise, cP）粘性溶液全剂量注射的成功率高于12.7mm STW注射器：在形成性研究中，前者成功率为63%，后者为42%。相较于市售款，新型8mm UTW注射器还具备更优异的使用便捷性与用户接受度；在形成性研究中，72%的受试者在注射粘性溶液时更青睐这款新型注射器。使用更短的注射针还可降低注射相关焦虑。此外，当采用非推荐注射技术时，使用8mm UTW注射器可将意外肌内注射的估算风险降低2至13倍。综上，相较于市售注射器，这款新型注射器在手动输送2 mL粘性溶液的场景中，可有效改善用户使用体验。