Replication Data for: Caustic paste application method affects wound size, wound healing, and scur development

Wounds caused by caustic paste application take longer to heal than wounds from hot iron disbudding. However, little work has focused on factors influencing healing following caustic paste disbudding. The objective of this study was to evaluate the effects of paste area and thickness on disbudding wound characteristics and healing progression. Female Holstein calves (n = 20) were randomly assigned to one of two paste areas: large (22 mm diameter) or small (12 mm diameter). Within each calf, one horn bud was treated with a thin layer of paste (1 mm) and the other with a thick layer (2 mm). Disbudding was performed between 4 to 6 d of age using multimodal pain management (sedation, local nerve block, and analgesics). Healing progress was monitored weekly through dimensional measurements (size and depth), wound tissue type classification, and pressure pain threshold (PPT) testing until they had fully re-epithelialized. The large paste area created wounds 60% larger than the small paste area and the thick paste created wounds 10% larger than the thin paste. The effect of paste area was observed throughout the healing process, but the effect of thickness was observed only while necrotic tissue was present. There was no difference in PPT between treatments and wound tissue types. Scurs were observed on all horn buds disbudded with the small paste area, but on none of the buds disbudded with the large area. These findings show that caustic paste application method affects wound size, wound healing and scur development.

使用苛性软膏（caustic paste）造成的去角伤口，其愈合时长较热烙铁去角术（hot iron disbudding）所致伤口更长。然而，目前针对苛性软膏去角术后伤口愈合影响因素的研究甚少。本研究旨在评估软膏涂抹面积与厚度对去角伤口特征及愈合进程的影响。将20头雌性荷斯坦犊牛（Holstein calves）随机分为两组，分别采用22mm直径的大涂抹面积与12mm直径的小涂抹面积的苛性软膏处理；每头犊牛的两个角芽分别施以1mm薄层与2mm厚层的软膏。所有犊牛均于4~6日龄时，在多模式镇痛管理（镇静、局部神经阻滞与镇痛药物）下接受去角手术。研究人员每周通过尺寸测量（伤口大小与深度）、伤口组织类型分类以及压力痛阈（pressure pain threshold, PPT）检测，对愈合进程进行监测，直至伤口完全实现再上皮化（re-epithelialized）。结果显示，大涂抹面积组的伤口尺寸较小面积组大60%，厚层软膏组的伤口尺寸较薄层组大10%。涂抹面积对伤口愈合的影响贯穿整个愈合周期，而软膏厚度的影响仅在坏死组织存在阶段可被观测到。不同处理组与伤口组织类型间的压力痛阈无显著差异。所有采用小面积软膏去角的角芽均观察到残角（scurs），而大面积软膏去角的角芽未出现残角。本研究结果表明，苛性软膏的涂抹方式会对伤口尺寸、伤口愈合及残角发育产生影响。