Multi-Residue Method for Determination of Thirty-Five Pesticides, Pharmaceuticals and Personal Care Products in Water Using Ionic Liquid-Dispersive Liquid-Liquid Microextraction Combined with Liquid Chromatography-Tandem Mass Spectrometry

Ionic liquid-dispersive liquid-liquid microextraction (IL-DLLME) was used for the determination of different chemical classes of analytes for the first time. Limits of quantification (LOQs) ranged from 0.5 to 2.5 µg L-1, and the linearity ranged from the LOQ of each compound to 50 µg L-1. Recoveries ranged from 70 to 120% for the compounds, with relative standard deviations less than 18%. The proposed method demonstrates for the first time that sample preparation by IL-DLLME and determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS) can be used successfully for the simultaneous extraction of 19 kinds of pesticides and 16 PPCPs from water samples. In addition, to eliminate the environmental risk of waste solvent disposal, this technique uses a low-toxicity extraction solvent. Finally, the analytical method proposed was applied successfully in analysis in surface water samples.

离子液体-分散液液微萃取（IL-DLLME）首次被应用于不同化学类别分析物的检测。定量限（LOQs）范围为0.5至2.5 μg·L⁻¹，线性范围覆盖各化合物的定量限至50 μg·L⁻¹。目标化合物的回收率介于70%至120%之间，相对标准偏差小于18%。本研究首次证实，采用离子液体-分散液液微萃取进行样品前处理、结合液相色谱-串联质谱（LC-MS/MS）进行检测的方法，可成功从水样中同时萃取19种农药与16种药物及个人护理用品（Pharmaceuticals and Personal Care Products, PPCPs）。此外，为消除废弃溶剂处置带来的环境风险，该技术采用低毒性萃取溶剂。最后，所提出的分析方法已成功应用于地表水样的检测分析。