High-throughput metabolomics for discovering potential biomarkers and identifying metabolic mechanisms in aging and Alzheimer’s disease

To analyse the plasma metabolites related to aging, we conducted an untargeted metabolomics analysis using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry in a two-stage cross-sectional study. In total, 669 metabolites were significantly altered with aging.

为分析与衰老相关的血浆代谢物，我们在一项两阶段横断面研究（two-stage cross-sectional study）中，采用超高效液相色谱-四极杆飞行时间质谱（ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry）开展了非靶向代谢组学（untargeted metabolomics）分析。总计有669种代谢物随衰老进程发生显著改变。