Additional file 9: Table S5. of Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

Asthma associated genes identified via differential network analysis of CD4 T cell responses to HDM. Genes with both upregulated expression and coexpression patterns (region 3, P = 0.0009) were identified in the HDM-sensitized atopics with asthma compared to HDM-sensitized atopics without asthma using differential network analysis. Genes identified were exclusively from the blue module (Fig. 6b) with the exception of *PRPS1 (brown module). (XLS 29 kb)

本数据集收录通过对CD4 T细胞对抗屋尘螨（HDM）的应答开展差异网络分析所鉴定出的哮喘相关基因。相较于屋尘螨致敏且无哮喘的特应性受试者，在屋尘螨致敏伴哮喘的特应性受试者中，通过该分析方法鉴定得到同时具备表达上调与共表达特征的基因（区域3，P=0.0009）。所鉴定出的基因均来自蓝色模块（图6b），仅*PRPS1除外，该基因属于棕色模块。（XLS 29 KB）