Synthesis of Fluorinated Cyclopropyl Amino Acid Analogues: Toward the Synthesis of Original Fluorinated Peptidomimetics.

A straightforward, easy, and practical access to various
amino
acid analogues (methionine, leucine, lysine, and arginine) from a
unique fluorinated cyclopropane scaffold is described. Moreover, the
synthesis, for the first time, of one tripeptide incorporating a fluorinated
cyclopropane amino acid (FCAA) analogue is reported.

本研究报道了一种从独特氟化环丙烷骨架（fluorinated cyclopropane scaffold）出发，便捷、实用且直接制备多种氨基酸类似物（涵盖甲硫氨酸、亮氨酸、赖氨酸及精氨酸）的合成路径。此外，本研究首次报道了一种掺入氟化环丙烷氨基酸（fluorinated cyclopropane amino acid，FCAA）类似物的三肽的合成方法。