Supplementary Material for: Resection of Renal Cell and Prostate Carcinoma Sternum Metastases with Long-Term Follow-Up: A Report of 2 Cases

<b><i>Introduction:</i></b> Rarely solitary sternum metastases are addressed by resection. Two additional cases are presented as they are interesting because of their long-term follow-up. <b><i>Case Presentation:</i></b> Case 1: A renal cell carcinoma was treated by transabdominal nephrectomy at age 64. Right iliac bone and sternum metastases were diagnosed 7 months later and treated by internal hemipelvectomy followed by sternum metastasectomy 6 weeks after the internal hemipelvectomy. At 12-year follow-up, the patient appears disease free. Case 2: Prostate cancer was treated by prostatectomy at age 67. A subsequent solitary sternum metastasis was resected 10 years later for persistent PSA-activity despite repeated radiotherapy. The patient remains asymptomatic for 3 years now. <b><i>Conclusion:</i></b> Resection of sternum metastases may have curative potential and should be considered in tumours known to be rather resistant to chemo- and/or radiotherapy.

<b><i>引言：</i></b> 胸骨孤立性转移瘤的手术切除治疗较为罕见。本文新增两例报告病例，二者均具备完整长期随访资料，具有较高临床研究价值。
<b><i>病例报告：</i></b>
病例1：患者64岁时因肾细胞癌（renal cell carcinoma）接受经腹肾切除术（transabdominal nephrectomy）。术后7个月确诊右侧髂骨及胸骨转移瘤，先行内半骨盆切除术（internal hemipelvectomy），术后6周再行胸骨转移瘤切除术（sternum metastasectomy）。经12年随访，患者处于无病生存状态。
病例2：患者67岁时因前列腺癌接受前列腺切除术（prostatectomy）。术后10年确诊孤立性胸骨转移瘤，尽管已接受多次放射治疗，但患者前列腺特异性抗原（Prostate-Specific Antigen, PSA）水平仍持续异常，遂行转移瘤切除术。截至目前，患者已无症状生存3年。
<b><i>结论：</i></b> 胸骨转移瘤的手术切除具备治愈潜力，对于对化学治疗和/或放射治疗抵抗性较强的肿瘤，可考虑采用手术切除治疗。