Additional file 6 of Ceftiofur treatment of sows results in long-term alterations in the nasal microbiota of the offspring that can be ameliorated by inoculation of nasal colonizers

Additional file 6. Figure S2. Heatmap representing the top 25 species by average abundance with Bray Curtis coefficient (A and C) and top 25 pathways by average abundance by Spearman correlation coefficient (B and D). Pregnant sows were treated with ceftiofur or remained untreated. A group of piglets born to treated sows remained nontreated (TS group), while piglets born to non-treated sows were treated with ceftiofur (TP group). A group of piglets were inoculated with selected colonizers of the upper respiratory tract either born to ceftiofur-treated sows (TS-IP) and to non-treated sows (IP group). As control, piglets born to non-treated sows remained non-treated. Groups TS, TP and control groups are compared in panels A and B. Groups IP, TS-IP and control are compared in panels C and D.

补充材料6：图S2。本热图展示了基于平均丰度排序前25的物种（采用Bray Curtis系数，对应面板A与C），以及基于平均丰度排序前25的通路（采用斯皮尔曼相关系数，对应面板B与D）。妊娠母猪被给予头孢噻呋（ceftiofur）处理或不予处理：由经处理母猪所产的一组仔猪未接受任何处理（TS组），而由未处理母猪所产的仔猪则接受头孢噻呋处理（TP组）；另有一组仔猪分别由头孢噻呋处理母猪所产（TS-IP组）与未处理母猪所产（IP组），并接种了筛选出的上呼吸道定植菌；对照组为未处理母猪所产且未接受任何处理的仔猪。面板A与B对TS组、TP组及对照组进行比较，面板C与D则对IP组、TS-IP组及对照组进行比较。