The frequency of the adverse events according to the occurrence of WRN.

†Post event (INR>3) 1 month.††Post event (INR>3) 3 month.†††Acute disease includes infectious disease, ischemic heart disease, cerebrovascular disease, injuries, and poisoning.†事件发生后（国际标准化比值（International Normalized Ratio）>3）1个月。††事件发生后（国际标准化比值（International Normalized Ratio）>3）3个月。†††急性疾病涵盖传染病、缺血性心脏病、脑血管疾病、损伤及中毒。