Protective effects of swimming exercises on murine tumor-induced cardiac inflammation and apoptosis by suppressing PI3K-AKT pathway

o investigate the intervention effect of aerobic exercise on cardiac dysfunction caused by tumor growth, and to explore its mechanism of action. Animals were implanted with CT-26 metastatic tumors in mice. The exercise method was swimming, with two daily interventions of 30 minutes each. 6 days a week for 4 weeks; To investigate the impact of swimming exercise intervention on cardiac function caused by tumor growth, we conducted experiments such as transcriptome sequencing, cardiac ultrasound, and protein detection to explore the mechanism of its effect. We conducted an animal experiment using CT-26 transplanted tumor mice and combined it with swimming exercise intervention to observe the effect of aerobic exercise on the intervention of cardiac dysfunction caused by tumor growth, and to explore its mechanism.

本研究旨在探讨有氧运动对肿瘤生长所致心功能障碍的干预效果，并探索其作用机制。实验以接种CT-26转移性肿瘤的小鼠为对象，运动干预方案为游泳：每日进行2次干预，每次30分钟，每周干预6天，持续4周。为探究游泳运动干预对肿瘤生长所致心功能的影响，本研究开展转录组测序、心脏超声、蛋白检测等实验以解析其作用机制。本研究采用CT-26移植瘤小鼠模型联合游泳运动干预，观察有氧运动对肿瘤生长所致心功能障碍的干预效果，并探索其潜在作用机制。