TevCas9 activity in HEK 293 cells. Homo sapiens

The purpose of this study was to determine the types and frequencies of insertions or deletions caused by a CRISPR-related genome-editing nuclease, TevCas9, at 4 on-target sites versus types and frequencies of insertions or deletions caused by Cas9 in HEK 293 cells.本研究旨在明确CRISPR相关基因组编辑核酸酶（CRISPR-related genome-editing nuclease）TevCas9在4个靶位点所引发的插入缺失的类型与频率，并将其与Cas9在HEK 293细胞中引发的插入缺失的类型及频率进行对比。