基于自由机理的、银催化芳香杂环母核C-2位选择性烷基化的合成新方法

建立了基于自由机理的、银催化芳香杂环C-2位选择性烷基化的合成新方法。在研究过程中，我们使用环季醇为原料，利用环的张力，在银催化剂的作用下，将环打开生成伯烷基自由基，然后与芳香杂环发生选择性地C-H功能化。该方法具有底物普适性（多种芳香杂环和环季醇）、条件温和、环境友好（水溶液）等诸多优点。数据记录数33页。A novel synthetic method for silver-catalyzed selective C-2 alkylation of aromatic heterocycles via a free radical mechanism has been developed. In this study, cyclic tertiary alcohols were employed as starting materials. By leveraging the inherent ring strain, the substrates undergo ring cleavage under silver catalysis to generate primary alkyl radicals, which subsequently engage in selective C-H functionalization with aromatic heterocycles. This method boasts multiple advantageous features, including a broad substrate scope (compatible with diverse aromatic heterocycles and cyclic tertiary alcohols), mild reaction conditions, and environmental compatibility with aqueous reaction media. A total of 33 pages of data records are included.