IS THE EFFECT OF HOMOEOPATHIC MEDICINE DIFFERENT FROM THE EFFECT OF PLACEBO IN HEALTHY INDIVIDUALS? – A RANDOMIZED, BLINDED, CONTROLLED, THREE ARMED HOMOEOPATHIC PATHOGENETIC TRIAL ON ELECTRO-PHOTONIC IMAGE CHANGES.

“A RANDOMISED, BLINDED, PLACEBO-CONTROLLED, THREE ARMED PARALLEL STUDY ON ELECTROPHOTONIC IMAGE CHANGES DURING HOMOEOPATHIC PATHOGENETIC TRIAL USING MOLECULAR AND ULTRA-MOLECULAR DOSES - A REPROVING OF BELLADONNA” ABSTRACT: Background: Homoeopathic drug proving is the process of understanding the pathogenetic powers of the dynamised Homoeopathic drugs on healthy human beings. In homoeopathic drug proving due to the biomimicry of production of disease symptoms, there are tremendous chances for the altered electron communication which may produce changes in the Electro-photonic Emission. Although controversies exist on the action of Belladonna in the healthy human provers (Good year et al (1998), H. Wallah et al (2001), S Brien et al(2003)). This study takes up the challenge to re-evaluate the efficacy of Belladonna in homoeopathic pathogenetic trial in the molecular and ultra-molecular doses. Method: Randomised, blinded, placebo-controlled three-armed (Belladonna6C, Belladonna200C and Placebo) parallel study (n = 150) conducted in National Institute of Homoeopathy, India. The study design was framed as a four-week protocol consisting of Pre-Intervention period, Intervention Period, Post Intervention period for each participant. Primary and Secondary Outcome Measures are Twelve parameters of Electro Photonic Imaging [EPI] technique and Q-Form-02 (30 items, Likert scale questionnaire) respectively. Result: The analysis showed a statistically significant difference in eight parameters (P-value <0.05,) out of twelve parameters and the Form Coefficient parameter (P-value <0.001) revealed the effect of placebo during the run-in phase. The questionnaire Q-Form-02 analysis revealed a significant difference among the three groups. The post hoc analysis showed the number of symptoms and the scores among groups depicted the trend: Belladonna 6C > Belladonna 200C > Placebo. Conclusion: We may conclude that the Electro Photonic Emissions from the human body may serve as a parameter to differentiate the placebo effect from the Homoeopathic medicine effect in the Homoeopathic Pathogenetic Trial [Trial Registration: CTRI/ 2018/03/012290].

# 一项针对采用分子与超分子剂量的顺势疗法致病试验期间电子光子图像变化的随机、盲法、安慰剂对照三臂平行研究——颠茄重验证试验

摘要：
背景：顺势疗法药物致病试验（homoeopathic drug proving）是指明确经动态化处理的顺势疗法药物对健康人体的致病潜能的过程。在顺势疗法药物致病试验中，由于疾病症状生成的仿生模拟机制，电子通信发生改变的概率极高，这可能引发电子光子发射（Electro-photonic Emission）的变化。尽管针对颠茄（Belladonna）在健康试验受试者中的作用存在诸多争议（Good year等，1998；H. Wallah等，2001；S Brien等，2003），本研究仍直面挑战，旨在重新评估分子与超分子剂量下颠茄在顺势疗法致病试验中的效用。

方法：本研究于印度国家顺势疗法研究院开展，为随机、盲法、安慰剂对照三臂平行试验（分为颠茄6C组、颠茄200C组与安慰剂组），样本量为150例。研究方案为期四周，涵盖所有受试者的干预前阶段、干预阶段与干预后阶段。主要结局指标为12项电子光子成像（Electro Photonic Imaging [EPI]）技术参数，次要结局指标为Q-Form-02量表（含30个条目，采用李克特（Likert scale）量表评分的问卷）。

结果：数据分析显示，12项参数中有8项存在统计学显著性差异（P值<0.05）；其中形状系数参数（Form Coefficient parameter）的P值<0.001，该参数可揭示导入阶段的安慰剂效应。Q-Form-02量表分析显示三组间存在显著差异。事后分析（post hoc analysis）结果表明，各组的症状数量与评分呈现如下趋势：颠茄6C组 > 颠茄200C组 > 安慰剂组。

结论：本研究可得出结论，人体的电子光子发射可作为区分顺势疗法致病试验中安慰剂效应与顺势疗法药物效应的评价参数。【试验注册编号：CTRI/2018/03/012290】