Metagenomic analysis of nasal swabs from a pediatric cohort with respiratory symptoms. Homo sapiens

The overall objective of this study is to conduct a pilot study of PREMISE using the emerging pathogen, enterovirus (EV) D68, to demonstrate utility of immunologic surveillance for future emerging pathogens. The goal of this pilot study is to create a biorepository of blood specimens pre- and post- EV seasons for use in immunologic assessments of the host response to EV-D68 to drive development of future diagnostic, therapeutic, and preventative tools and improve understanding of the epidemiology of EV-D68.

本研究的总体目标为以新型病原体肠道病毒D68（enterovirus D68，EV-D68）为研究对象，开展PREMISE的先导性研究，以验证免疫监测技术在应对未来新型病原体方面的应用价值。本先导研究的目标是构建肠道病毒流行季前后的血液标本生物样本库，用于开展宿主针对EV-D68的免疫应答相关免疫学评估，以此推动未来诊断、治疗与预防工具的研发，并加深对EV-D68流行病学特征的认知。