Data for the article 'Association between various physical activity domains and overall cancer risk, National Health and Nutrition Examination Survey (NHANES) 2007-2018' submitted to PLOS one

<b>Title: </b>"Association between various physical activity domains and overall cancer risk, National Health and Nutrition Examination Survey (NHANES) 2007-2018" <b>Purpose:</b><b> </b>There are very few studies concurrently evaluating the association between multiple physical activity (PA) domains and cancer prevalence. Therefore, this study aims to fill this gap by investigating the link between multiple PA subdomains [occupational PA (OPA), transportation-related PA (TPA), leisure-time PA (LTPA), and total PA] and the likelihood of cancer. <b>Method:</b><b> </b>The data from National Health and Nutrition Examination Survey (NHANES) 2007-2008, 2009-2010, 2011-2012, 2013-2014, 2015-2016, and 2017-2018 were used in this study. Cancers are the primary outcome variable of interest in this study. PA was self- or proxy-reported using the Global Physical Activity Questionnaire (GPAQ). Multivariable logistic regression models were used, adjusted for covariates. <b>Results:</b><b> </b>The trend analysis revealed that the prevalence of cancer statistically decreased with the increase in total PA amount. The participants achieving twice the minimum recommended PA guidelines (≥300 minutes) for total PA were 32% [0.68 (0.54, 0.86)] less likely to have cancer. However, significant associations between three PA subdomains (OPA, TPA, and LTPA) and cancers were not found in this study. <b>Conclusion:</b><b> </b>There is no significant association between any of these three single PA subdomains and cancer prevalence other than total PA. Therefore, this study recommends clinical practice should prioritize promoting comprehensive PA that integrates OPA, TPA, and LTPA to achieve at least 150 minutes per week (i.e. per seven days) initially and progressing towards 300 minutes for optimal cancer prevention.

**研究标题：** 不同身体活动维度与总体癌症风险的关联——2007-2018年美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）数据
**研究目的：** 目前同时评估多维度身体活动（physical activity, PA）与癌症患病率关联的研究较为匮乏。本研究旨在填补这一研究空白，探讨四类身体活动亚维度——职业性身体活动（occupational PA, OPA）、交通出行相关身体活动（transportation-related PA, TPA）、闲暇时间身体活动（leisure-time PA, LTPA）以及总体身体活动（total PA）——与癌症发生风险的关联。
**研究方法：** 本研究使用了2007-2008、2009-2010、2011-2012、2013-2014、2015-2016及2017-2018周期的美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）数据。本研究的主要结局变量为癌症发生情况。身体活动信息通过全球身体活动问卷（Global Physical Activity Questionnaire, GPAQ）由受访者自行或代理人报告。本研究采用多变量logistic回归模型，并对混杂因素进行了校正。
**研究结果：** 趋势分析结果显示，随着总体身体活动量的增加，癌症患病率呈显著下降趋势。当受访者的总体身体活动量达到推荐最低标准的两倍（≥300分钟/周）时，其患癌风险较参照组降低32% [OR=0.68, 95%CI: 0.54, 0.86]。然而，本研究未发现其余三个身体活动亚维度（OPA、TPA与LTPA）与癌症发生存在显著关联。
**研究结论：** 除总体身体活动外，本研究未发现其余三个单一身体活动亚维度与癌症患病率存在显著关联。据此，本研究建议临床实践中应优先推广整合职业性、交通出行相关及闲暇时间身体活动的综合身体活动方案，初期目标为每周至少完成150分钟身体活动，后续逐步提升至300分钟，以实现最佳的癌症预防效果。