Sequence variants and allele distribution of genes in six rat MHC haplotypes.

aAll genes except RT1-DMa and Tapbp are encoded within the Tcs2 locus.bSize of the coding sequences (cds) in bp.cTotal number of synonymous and nonsynonymous SNPs in the cds.dTotal number of insertions/deletions on gene level.eAllele distribution between MHC haplotypes; DA (RT1a), DA.1F (RT1f), DA.1I (RT1i), DA.1H (RT1h), DA.1U (RT1u). Sequence information for RT1n was obtained from NCBI GenBank.fTotal number of amino acid substitutions.gNumber of alternative isoforms at the protein level.hBtnl2 was analyzed in only two strains.ISequence information for RT1-DOb refers to the full-length transcript of this gene (see Fig. S1 for alternative transcript).

a. 除RT1-DMa与Tapbp外，其余所有基因均由Tcs2基因座编码。
b. 编码序列（coding sequences, CDS）的长度，单位为碱基对（base pair, bp）。
c. 编码序列内同义单核苷酸多态性（single nucleotide polymorphism, SNP）与非同义单核苷酸多态性的总数量。
d. 基因层面插入/缺失变异的总数量。
e. 主要组织相容性复合体（major histocompatibility complex, MHC）单倍型间的等位基因分布情况；涉及的单倍型包括DA（RT1a）、DA.1F（RT1f）、DA.1I（RT1i）、DA.1H（RT1h）、DA.1U（RT1u）。RT1n的序列信息来源于NCBI GenBank。
f. 氨基酸替换的总数量。
g. 蛋白质层面的可变异构体数量。
h. Btnl2仅在两个品系中完成分析。
i. RT1-DOb的序列信息对应该基因的全长转录本，可变转录本详见补充图S1。