Supplementary Tables S1-S10 from Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia

XLSX file - 370K, Annotation of CpG-site interrogating probes (S1); Summary of RNA-sequencing generated for each patient sample on the SOLiD 4 system (S2); Percentage of probes within a given cross-sample standard deviation (SD)-range for normal (N) and tumor (T) samples (S3); Tumor sample methylation level variability (S4); Amount of gene-associated CpG-sites, amount of RefSeq genes and their isoforms in each CpG-site region, and region-specific median Spearman's rho (S5); Spearman's ranked correlation rho between methylation and transcript expression level with significance level for each patient in each CpG-site region (S6); Probes displaying significant differential methylation in samples carrying the t(12;21) translocation (S7); Genes associated with t(12;21)-specifically methylated probes (S8); Genes identified as uniformely hypo- or hypermethylated in samples carrying the t(12;21) translocation, and associated methylation and transcript expression levels (S9); Gene networks generated by IPA (S10)

XLSX格式文件（370K）包含以下内容：CpG位点检测探针注释（S1）；基于SOLiD 4测序系统生成的各患者样本RNA测序结果汇总（S2）；正常（N）与肿瘤（T）样本中落入指定跨样本标准差（SD）区间内的探针占比（S3）；肿瘤样本甲基化水平变异度（S4）；各CpG位点区域内基因关联CpG位点数量、RefSeq基因及其转录本亚型数量，以及该区域的斯皮尔曼秩相关系数rho中位数（S5）；各CpG位点区域内各患者的甲基化水平与转录本表达水平之间的斯皮尔曼秩相关系数rho及其显著性水平（S6）；携带t(12;21)易位的样本中呈现显著差异甲基化的探针（S7）；与t(12;21)特异性甲基化探针关联的基因（S8）；携带t(12;21)易位的样本中被鉴定为一致性低甲基化或高甲基化的基因，及其关联的甲基化水平与转录本表达水平（S9）；IPA（Ingenuity通路分析）生成的基因网络（S10）