We have sequenced, assembled and annotated the genome of Clostridium sordellii strain SSCC33589. Paraclostridium sordellii strain:SSCC33589

Clostridium sordellii is an anaerobic bacterium associated with rare but severe infections of man and animals. Human infections are associated with trauma, toxic shock and often-fatal gynaecological infections. Some strains are known to produce the large clostridial cytotoxins TcsH and TcsLH, relatives of the cytotoxins found in C. difficile, C. novyi and C. perfringens. We have undertaken a genomic analysis of a collection of C. sordellii strains derived from cases of clinical or veterinary disease. Phylogenetic analysis reveals a highly genetically diverse species. The majority of strains do not encode tcsL or tcsH, but all strains encode the putative virulence factors sordellilysin, phospholipase C and neuraminidase. Where tcsL or tcsH are present, these are localised on a plasmid. Large scale sequencing on this neglected pathogen has to date been limited, these genomes will facilitate further research on this important pathogen.

索氏梭菌（Clostridium sordellii）是一种厌氧菌，可引发人和动物罕见但病情严重的感染。人类感染常与创伤、中毒性休克相关，且多为致死性妇科感染。部分菌株可产生大型梭菌毒素TcsH与TcsLH，这类毒素与艰难梭菌（C. difficile）、诺维氏梭菌（C. novyi）及产气荚膜梭菌（C. perfringens）中的毒素为同源物。本研究对一批源自临床或兽医疾病病例的索氏梭菌菌株开展了基因组分析。系统发育分析结果显示，该物种具有极高的遗传多样性。绝大多数菌株不携带tcsL基因或tcsH基因，但所有菌株均编码推定毒力因子索氏溶素（sordellilysin）、磷脂酶C（phospholipase C）及神经氨酸酶（neuraminidase）。当菌株携带tcsL或tcsH基因时，二者均定位于质粒上。迄今为止，针对这一被忽视的重要病原体的大规模测序研究仍较为有限，本次获得的基因组数据将为该病原体的后续研究提供重要助力。