A Formal Total Synthesis of Platencin

The readily available and enantiomerically pure trienes 12 undergo a thermally induced intramolecular Diels−Alder reaction to give the corresponding mixture of compounds 13 and 14. This mixture has been elaborated to an advanced intermediate associated with Nicolaou’s recently reported total synthesis of the natural enantiomeric form of the antibiotic platencin (2).

易得且对映体纯的三烯烃12会发生热诱导分子内狄尔斯-阿尔德（Diels−Alder）反应，得到相应的化合物13与14的混合物。该混合物经衍生得到与尼古拉乌（Nicolaou）近期报道的抗生素普拉坦星（platencin，2）天然对映体形式全合成相关的关键中间体。