PrseDRB.fasta

This repository contains R code and data for our manuscript (submitted):"<b>Hidden zoonotic risk: immunogenetic-pathogen networks shrink in a generalist rodent inhabiting disturbed landscapes</b>"by Ramona Fleischer, Georg Joachim Eibner, Nina Isabell Schwensow, Sofia Paraskevopoulou, Gerd Mayer, Victor Max Corman, Christian Drosten, Kerstin Wilhelm, Alexander Christoph Heni, Simone Sommer and Dominik Werner SchmidIn this work we examined the effect of anthropogenic disturbance at the landscape level on neutral genetic diversity and diversity at the important immune gene region of the Major Histocompatibility Complex class II and multiple pathogen infections in a common neotropical rodent generalist, the Tomey's spiny rat (<i>Proechimys semispinosus</i>).<br>The file PrseDRB.fasta contains all <i>Proechimys semispinosus</i> MHC DRB exon 2 sequences with corresponding names that we obtained from sequencing.

本仓库包含我们投稿的手稿《**隐匿的人畜共患病风险：受干扰生境中广食性啮齿动物的免疫遗传-病原体网络缩减**》的R代码与配套数据，手稿作者为Ramona Fleischer、Georg Joachim Eibner、Nina Isabell Schwensow、Sofia Paraskevopoulou、Gerd Mayer、Victor Max Corman、Christian Drosten、Kerstin Wilhelm、Alexander Christoph Heni、Simone Sommer及Dominik Werner Schmid。

本研究以常见的新热带区广食性啮齿动物——托梅棘鼠（*Proechimys semispinosus*）为对象，探讨了景观尺度人为干扰对其中性遗传多样性、主要组织相容性复合体II类（Major Histocompatibility Complex class II, MHC II）关键免疫基因区域多样性及该物种多重病原体感染状况的影响。

文件PrseDRB.fasta收录了我们通过测序获得的全部托梅棘鼠MHC DRB外显子2序列及其对应命名。