Transition-Metal-Catalyzed Hydrosulfoximination and Oxidation Reaction for the Synthesis of Sulfoximine Derivatives

We report herein a Au/Ag-cocatalyzed chemoselective hydrosulfoximination reaction of simple ynamides with free NH-sulfoximines, which produces the N-alkenylated sulfoximidoyl derivatives with quantitative atom efficiency and good to excellent yields. Further elaborations of the enamine isomers under Ru-catalyzed oxidative conditions to cleave the CC double bonds can selectively afford urea-type sulfoximines. The aforementioned catalytic reactions provide new opportunities for the convergent and straightforward access to sulfoximine derivatives.

本文报道了一例金/银共催化的化学选择性氢亚磺酰亚胺化（hydrosulfoximination）反应，以简单炔酰胺（ynamides）与游离NH-亚磺酰亚胺（free NH-sulfoximines）为底物，可生成N-烯基化亚磺酰亚胺酰基衍生物，且具有定量原子经济性与良好至优异的产率。对该反应得到的烯胺异构体（enamine isomers），在钌催化（Ru-catalyzed）氧化条件下进行衍生化，通过切断碳碳双键，可选择性得到脲型亚磺酰亚胺类产物。上述催化反应为汇聚式且简便地获取亚磺酰亚胺类衍生物提供了新的研究路径。