LONG-TERM OUTCOMES OF PURULENT-NECROTIC COMPLICATIONS AGAINST THE BACKGROUND OF DIABETES MELLITUS: ACHIEVEMENTS AND SHORTCOMINGS

Determination of biochemical processes, endogenous intoxication and histomorphological and planimetric indicators in purulent-necrotic lesions of the foot in an experimental way and in patients with purulent-necrotic processes in diabetes mellitus, the condition of the IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, and INF-γ system based on the dynamics of cytokine levels was studied. Complex surgical treatment of the drug Reomannisol corrects the balance of cytokines, allowing them to have an antioxidant effect on the cytokine system.