Comparative transcriptomic analyses of human lung epithelial cells infected with wild-type SARS-CoV-2 and its variant with a 12-bp

To elucidate the mechanism of SARS-CoV-2 replication and immunogenicity, we performed a comparative transcriptome profile of mRNA and long non-coding RNAs (lncRNAs) in human lung epithelial cells infected with SARS-CoV-2 wild strain (8X) and the variant with a 12-bp deletion in the E gene

为阐明新型冠状病毒（SARS-CoV-2）的复制机制与免疫原性，本研究对感染了SARS-CoV-2野生毒株（8X）以及E基因携带12bp缺失变异的人肺上皮细胞，开展了信使RNA（mRNA）与长链非编码RNA（lncRNAs）的比较转录组分析。