Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute Chagas disease in a domiciliated dog in the western Amazon

Abstract Chagas disease is caused by the protozoan Trypanosoma cruzi. Seven lineages have been identified based on different molecular markers, namely TcI, TcII, TcIII, TcIV, TcV, TcVI, and TcBat. Dogs play the role of epidemiological sentinels being domestic reservoirs of T. cruzi. The aim of the current study was to report the first case of CD in a domestic dog in Manaus, Amazonas, Brazil, infected with T. cruzi DTU TcIV. We hope our report encourages veterinarians and surveillance professionals to a take a deeper look at T. cruzi infection in domestic animals.

摘要：查加斯病（Chagas disease）由原生动物克氏锥虫（Trypanosoma cruzi）引发。目前基于不同分子标记已鉴定出7个克氏锥虫谱系，分别为TcI、TcII、TcIII、TcIV、TcV、TcVI及TcBat。犬类作为克氏锥虫的家养储存宿主，可充当流行病学监测哨兵。本研究旨在报告巴西亚马孙州马瑙斯市首例家养犬感染克氏锥虫离散分型单元（Discrete Typing Unit，DTU）TcIV的查加斯病病例。本研究希望该病例报告能推动兽医及公共卫生监测专业人员更加重视家养动物的克氏锥虫感染情况。