Participant characteristics (n = 276).

BackgroundOlder adults with polypharmacy are more prone to medication errors. People with low educational attainment have more difficulties in taking their medications.ObjectivesThis study aimed to identify the extent of medication self-administration errors (MSEs) and the contributing factors among illiterate and low-literate community-dwelling older adults with polypharmacy.MethodThe present cross-sectional study was conducted among people aged 60 and above. The data were collected using the sociodemographic, clinical, and Belief about Medicines Questionnaires (BMQ). To determine the extent of MSE, a medication error checklist was used. The negative binomial hierarchical regression model in the five blocks was performed.ResultsThe final sample size was 276 people. The frequency of MSEs in the last 6 months was 69.2%. Sixteen percent of participants had made four or more mistakes. The most common MSEs were forgetting, improper taking of medications with food, improper timing, incorrect dosage (lower dose), and forgetting the doctor’s instructions. Near 18% of participants reported adverse events following their mistakes. The significant predictors of MSEs were being completely illiterate (p = 0.021), the higher number of doctor visits per year (p = 0.014), irregularly seeing doctors (p ConclusionDespite the high prevalence of MSEs among older patients, practical strategies to deal with them at their homes have not been established among health systems. MSE as a multifactorial event can be caused by a collection of internal and external factors. Further studies to identify the role of patients, clinicians, procedures, and systems in developing MSEs as interconnected components are needed.### 研究背景 合并多重用药（polypharmacy）的老年人群更易出现药物给药差错，受教育水平偏低的群体在服药过程中面临更多障碍。 ### 研究目的 本研究旨在明确合并多重用药的文盲及低文化水平居家社区老年群体的药物自我给药差错（medication self-administration errors, MSEs）发生情况及其影响因素。 ### 研究方法 本横断面研究（cross-sectional study）纳入60岁及以上人群作为研究对象，研究数据通过社会人口学问卷、临床问卷与用药信念问卷（Belief about Medicines Questionnaires, BMQ）采集。为评估MSEs的发生程度，本研究采用药物差错核查表，数据分析采用分五个区块构建的负二项分层回归模型。 ### 研究结果 最终纳入有效样本276例。过去6个月内MSEs的发生频率为69.2%，16%的受试者曾出现4次及以上给药差错。最常见的MSE类型包括漏服药物、未按要求与食物同服、给药时机不当、剂量错误（剂量不足）以及遗忘医嘱。近18%的受试者报告因给药差错出现了不良事件。MSEs的显著预测因素包括完全文盲（p = 0.021）、年就诊次数较多（p = 0.014）、不规律就诊（p ### 研究结论 尽管老年患者中MSEs的患病率居高，但医疗体系尚未建立起可在家庭场景下应用的有效应对方案。MSE属于多因素事件，可由一系列内、外因素共同引发。未来仍需开展进一步研究，明确患者、临床医师、诊疗流程及医疗体系作为相互关联的组成部分在MSEs发生发展中的具体作用。