Supplementary Material for: Effect Estimation of an Innovative Nursing Intervention to Improve Delirium among Home-Dwelling Older Adults: A Randomized Controlled Pilot Trial

<b><i>Aims:</i></b> Estimating the effect of a nursing intervention in home-dwelling older adults on the occurrence and course of delirium and concomitant cognitive and functional impairment. <b><i>Methods:</i></b> A randomized clinical pilot trial using a before/after design was conducted with older patients discharged from hospital who had a medical prescription to receive home care. A total of 51 patients were randomized into the experimental group (EG) and 52 patients into the control group (CG). Besides usual home care, nursing interventions were offered by a geriatric nurse specialist to the EG at 48 h, 72 h, 7 days, 14 days, and 21 days after discharge. All patients were monitored for symptoms of delirium using the Confusion Assessment Method. Cognitive and functional statuses were measured with the Mini-Mental State Examination and the Katz and Lawton Index. <b><i>Results:</i></b> No statistical differences with regard to symptoms of delirium (p = 0.085), cognitive impairment (p = 0.151), and functional status (p = 0.235) were found between the EG and CG at study entry and at 1 month. After adjustment, statistical differences were found in favor of the EG for symptoms of delirium (p = 0.046), cognitive impairment (p = 0.015), and functional status (p = 0.033). <b><i>Conclusion:</i></b> Nursing interventions to detect delirium at home are feasible and accepted. The nursing interventions produced a promising effect to improve delirium.

**<i>研究目的：</i>** 评估居家老年人群的护理干预对谵妄发生、发展及伴随的认知与功能损害的影响。**<i>研究方法：</i>** 本研究针对出院后持有家庭护理医疗处方的老年患者，采用前后对照设计开展随机先导临床试验。共纳入103例患者，其中51例被随机分配至试验组（Experimental Group, EG），52例分配至对照组（Control Group, CG）。除常规家庭护理外，老年护理专科护士于患者出院后48h、72h、7d、14d及21d为试验组提供针对性护理干预。所有患者均采用意识模糊评估法（Confusion Assessment Method, CAM）监测谵妄症状，并以简易精神状态检查表（Mini-Mental State Examination, MMSE）及卡茨-劳顿指数（Katz and Lawton Index）评估其认知与功能状态。**<i>研究结果：</i>** 在入组时及随访1个月时，试验组与对照组在谵妄症状（p=0.085）、认知损害（p=0.151）及功能状态（p=0.235）方面均无统计学差异。经校正分析后，试验组在谵妄症状（p=0.046）、认知损害（p=0.015）及功能状态（p=0.033）方面均展现出显著优势。**<i>研究结论：</i>** 居家开展的谵妄筛查护理干预具备可行性且易于被接受，该护理干预对改善谵妄相关症状具有良好的应用前景。