Association of baseline levels of t-PA antigen, D-dimer and VWF with coronary heart disease in the Reykjavik Study (1925 cases, 3616 controls).

*Smoking status, body mass index, systolic blood pressure and any history of diabetes mellitus at baseline.
†Total cholesterol and loge triglycerides.
When analyses were restricted to participants with complete information on C-reactive protein (1906 cases, 3573 controls), the odds ratios (95% CI) per 1 SD higher value of t-PA antigen were 1.26 (1.18, 1.33) when adjusting for age, sex and period of recruitment, 1.15 (1.07, 1.22) when additionally adjusting for non-lipid risk factors, 1.07 (0.99, 1.14) when additionally adjusting for lipid risk factors and 1.04 (0.97, 1.11) when additionally adjusting for C-reactive protein. Corresponding odds ratios were 1.01 (0.95, 1.07), 1.04 (0.98, 1.11), 1.07 (1.00, 1.14) and 1.05 (0.99, 1.12) for D-dimer and 1.12 (1.05, 1.18), 1.09 (1.02, 1.15), 1.09 (1.03, 1.16) and 1.06 (1.00, 1.13) for VWF.

* 基线时的吸烟状态、身体质量指数、收缩压及糖尿病既往史。
† 总胆固醇与自然对数转换甘油三酯（loge triglycerides）。
当分析仅纳入具备完整C反应蛋白（C-reactive protein）数据的受试者（1906例病例，3573例对照）时，每升高1个标准差（SD）的组织型纤溶酶原激活剂抗原（t-PA antigen）对应的优势比（95%置信区间，95% CI）为：校正年龄、性别及招募周期后为1.26（1.18, 1.33）；额外校正非脂质危险因素后为1.15（1.07, 1.22）；额外校正脂质危险因素后为1.07（0.99, 1.14）；额外校正C反应蛋白后为1.04（0.97, 1.11）。
针对D-二聚体（D-dimer），对应优势比依次为1.01（0.95, 1.07）、1.04（0.98, 1.11）、1.07（1.00, 1.14）及1.05（0.99, 1.12）；针对血管性血友病因子（von Willebrand factor, VWF），对应优势比依次为1.12（1.05, 1.18）、1.09（1.02, 1.15）、1.09（1.03, 1.16）及1.06（1.00, 1.13）。