Schematic diagram of possible mechanism of EGCG in protecting against CIN.

HO-1 expression is markedly enhanced by EGCG via activation of the Nrf2/HO-1 pathway. HO-1 is essential to the protective effect of EGCG on CIN in anti-oxidation and anti-inflammation. Dash-line arrow stands for unclear or multiple-step actions. Straight-line arrow stands for direct actions.

表没食子儿茶素没食子酸酯（EGCG）可通过激活核因子E2相关因子2（Nrf2）/血红素加氧酶1（HO-1）通路，显著上调HO-1的表达。HO-1是EGCG针对宫颈上皮内瘤变（CIN）发挥抗氧化、抗炎保护作用的必需因子。虚线箭头代表作用机制尚不明确或涉及多步骤的调控过程。实线箭头代表直接作用过程。