Successful treatment of narcolepsy with prednisolone

Narcolepsy is a chronic neurological disorder with symptoms that include excessive daytime sleepiness and cataplexy. While the traditional understanding of narcolepsy has been centered on genetic and autoimmune causes, recent studies have begun to explore connections with brain injury and mitochondrial diseases (mitochondriopathies). This paper reports a case of successful treatment of severe narcolepsy-like symptoms with prednisolone, a corticosteroid. This finding may lead to more targeted and personalized therapeutic approaches for individuals suffering from narcolepsy or narcolepsy-like symptoms linked to brain injury or mitochondrial dysfunction.

发作性睡病（Narcolepsy）是一种慢性神经系统疾病，临床症状涵盖日间过度嗜睡与猝倒症。传统认知中，发作性睡病的病因多聚焦于遗传与自身免疫异常，而近期研究开始探索其与脑损伤、线粒体疾病（线粒体病，mitochondriopathies）的潜在关联。本研究报告1例采用糖皮质激素泼尼松龙成功治疗重度发作性睡病样症状的病例。该发现可为发作性睡病患者，或罹患与脑损伤、线粒体功能障碍相关的发作性睡病样症状的人群，提供更具针对性与个性化的治疗思路。