WES used for direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

We performed whole exome sequencing of tumor- as well as PBMC-derived DNA of five melanoma patients for identification of naturally presented patient-specific neoepitopes.EGA study EGAS00001002050

本研究对5例黑色素瘤患者的肿瘤来源DNA与外周血单个核细胞（Peripheral Blood Mononuclear Cell，PBMC）来源DNA开展全外显子组测序（whole exome sequencing），旨在鉴定天然呈递的患者特异性新表位（neoepitope）。该研究隶属于欧洲基因组表型档案（European Genome-phenome Archive，EGA）研究EGAS00001002050。